Safety
Enclomiphene side effects in men: what studies show
What the published studies say about enclomiphene side effects in men, what is still unknown, and what to ask a clinician before you start a program.
By Julian Caraulani · Updated November 13, 2026
Enclomiphene side effects in men are not well mapped. The large trials were short and reported hormone levels and sperm counts, not a full list of complaints. One clinic review found fewer side effects on enclomiphene than on its older relative, clomiphene. Online programs list enclomiphene from $98 a month, so know the evidence first.
Not in this price: $70 appointment · $95 new-patient labs, $124.50 follow-up labs. Price checked Nov 2 · Medication included · No email needed
This guide covers what the studies found, where the evidence stops, and what to ask before you begin. It is general information, not medical advice.
What enclomiphene is, in plain words
Enclomiphene is a daily pill. It makes the brain send a stronger signal to the testicles, so they make more of the body's own testosterone. It is not testosterone itself.
It is not an FDA-approved drug. Online programs sell a compounded version, which means a pharmacy makes it for each patient. The FDA says it does not verify the safety, effectiveness or quality of compounded drugs before they are sold (FDA). Our enclomiphene cost guide covers that status in more detail.
What the studies report
There is no FDA label for enclomiphene, so there is no official side effect list to quote. What exists is published research. We read the abstracts on PubMed, the US National Library of Medicine's research index, on November 13, 2026.
| Study | What it was | What it reported about safety |
|---|---|---|
| Kim et al., BJU Int 2016 | Two randomized trials, 16 weeks, overweight men aged 18 to 60 with low testosterone | Testosterone rose, and "Enclomiphene citrate maintained sperm concentration in the normal range" |
| Saffati et al., 2024 | A look back at 66 men at one Texas clinic who took clomiphene, then enclomiphene | "Adverse effects were statistically significantly less frequent with enclomiphene" |
| Hohl et al., 2025 | A pooled review of randomized trials of clomiphene or enclomiphene | Reported testosterone, LH and FSH results; the abstract lists no side effect findings |
| Tariq et al., 2026 | The story of one patient | An irregular heartbeat, "causality cannot be established" |
The best news is in the Texas review. Men had fewer problems with sex drive, energy and mood on enclomiphene than on clomiphene. The authors link that to a smaller change in estradiol, a form of estrogen.
Not in this price: $70 appointment · $95 new-patient labs, $124.50 follow-up labs. Price checked Nov 2 · Medication included · No email needed
Where the evidence is thin
Be honest about what these studies cannot tell you.
- Short trials. The main trials ran 16 weeks. We found no long-term trial of enclomiphene's effect on heart health, bones or the prostate.
- One clinic, no control group. The Texas review looked backward at charts. Its authors say "further research and more extensive studies are warranted."
- A narrow group. The trials enrolled overweight men whose low testosterone came from a weak brain signal. They say little about other men.
- No symptom scores. The trials tracked blood levels and sperm counts. A higher testosterone number does not prove you will feel better.
The heart case is one man with a past heart valve repair. The report says the arrhythmia came soon after he took more than prescribed. The authors state that "causality cannot be established," and that the drug's heart safety "remains poorly characterised." Read it as a reason to take only what you are prescribed and to tell the clinician about any heart history.
What to ask a clinician before you start
A good program should answer these in plain words:
- Which blood tests do I need first, and when will they be repeated?
- Is this product compounded, and which pharmacy makes it?
- What should I do if I notice a racing or uneven heartbeat?
- How long will I stay on it before we review whether it works?
- Is my fertility goal a fit for this pill or for another option?
Plans differ on blood tests. Some programs include them and others charge extra, so check the line on each plan. Our enclomiphene price table shows what each program lists, with dates.
How it compares with testosterone
Testosterone has a long FDA label with its own warnings. In 2025 the FDA added a blood pressure warning to every testosterone product (FDA). The Xyosted label also says testosterone can lower sperm production, and that the effect "may be irreversible" (Xyosted label).
Enclomiphene's appeal is that it kept sperm counts normal in the trials. Its cost is that the evidence is shorter and it has no approval. Our enclomiphene vs TRT guide lays out the trade-off. To compare programs on score and plan facts, see best TRT programs.
FAQ
What are the side effects of enclomiphene in men?
No official label list exists because the FDA has not approved enclomiphene. Published studies mostly report hormone levels and sperm counts. A 2024 clinic review found fewer problems with sex drive, energy and mood on enclomiphene than on clomiphene. Long-term effects are not well studied, so ask the prescribing clinician what to watch for.
Is enclomiphene safe?
The short trials found it raised testosterone and kept sperm counts normal. That is not proof of long-term safety. No FDA approval exists, and compounded versions are not checked by the FDA before sale. Safety depends on your health history, so a clinician who reviews your blood tests is the right judge.
Are there enclomiphene reviews from real users?
We do not quote user reviews, because they cannot be checked. We rely on published studies and each program's own plan pages. You can compare programs by rating, price and what is included on our best TRT programs page.
Does enclomiphene cause side effects in men less often than clomiphene?
In one Texas clinic review of 66 men, yes. The authors reported fewer adverse effects on enclomiphene. It looked back at records with no control group, so it is a hint, not proof. The authors call for larger studies.
Can enclomiphene affect fertility?
In two 16-week trials, sperm concentration stayed in the normal range on enclomiphene. It fell on testosterone gel. If you want children, tell the clinician before you start any treatment and ask how your sperm will be checked.
What should I do if I feel unwell on enclomiphene?
Contact the prescribing clinician. For chest pain, fainting or a racing heartbeat, seek urgent care. Do not take more than prescribed. The case report in the table involved a man who took more than his prescribed amount.
Next, see what each program lists on the enclomiphene price table, or compare options on best TRT programs.
Check this page with an AI assistant:ChatGPTPerplexityClaude
Not affiliated with OpenAI, Perplexity or Anthropic.